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KMID : 1102220170360010100
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Kidney Research and Clinical Practice
2017 Volume.36 No. 1 p.100 ~ p.104
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Syndrome of inappropriate antidiuretic hormone secretion associated with seronegative neuromyelitis optica spectrum disorder
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Oh Shin-Ju
Ihm Chun-Gyoo
Lee Tae-Won
Kim Jin-Sug
Kim Da-Rae
Park Eun-Ji
Jung Su-Woong
Lee Ji-Hoon
Heo Seo-Yoon
Jeong Kyung-Hwan
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Abstract
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The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential cause of hyponatremia of the central nervous system (CNS). Although SIADH has been reported to be associated with many other central nervous disorders, its association with neuromyelitis optica (NMO) or NMO spectrum disorders are rare. NMO is a demyelinating disorder characterized by optic neuritis and transverse myelitis. Aquaporin-4 (AQP4), which is the target antigen for a NMO autoantibody, is the predominant CNS water channel. However, some NMO patients show seronegative AQP4 antibody results. The spectrum of NMO has been changed, and new findings about the disease have been reported. Here, we report a case of seronegative NMO spectrum disorder associated with SIADH.
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KEYWORD
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Aquaporin-4, Neuromyelitis optica, Syndrome of inappropriate antidiuretic hormone secretion
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